Creating a clinical platform for carbon‐13 studies using the sodium‐23 and proton resonances

  1. Grist, James T. 14
  2. Hansen, Esben S.S. 7
  3. Sánchez‐Heredia, Juan D. 2
  4. McLean, Mary A. 15
  5. Tougaard, Rasmus 7
  6. Riemer, Frank 1
  7. Schulte, Rolf F. 6
  8. Kaggie, Joshua D. 1
  9. Ardenkjaer‐Larsen, Jan Henrik 23
  10. Laustsen, Christoffer 7
  11. Gallagher, Ferdia A. 1
  1. 1 Department of Radiology University of Cambridge Cambridge United Kingdom
  2. 2 Department of Health Technology Technical University of Denmark Kgs. Lyngby Denmark
  3. 3 GE Healthcare Chicago USA
  4. 4 Institute of Cancer and Genomic Sciences University of Birmingham Birmingham United Kingdom
  5. 5 CRUK Cambridge Institute Cambridge United Kingdom
  6. 6 GE Healthcare Munich Germany
  7. 7 MR Research Centre Aarhus University Aarhus Denmark
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Journal:
Magnetic resonance in medicine

ISSN: 0740-3194,  1522-2594

Year of publication: 2020

Volume: 84

Issue: 4

Pages: 1817-1827

Type: Article

DOI: 10.1002/MRM.28238 GOOGLE SCHOLAR

More publications in: Magnetic resonance in medicine

Abstract

Purpose: Calibration of hyperpolarized 13C-MRI is limited by the low signal from endogenous carbon-containing molecules and consequently requires 13C-enriched external phantoms. This study investigated the feasibility of using either 23Na-MRI or 1H-MRI to calibrate the 13C excitation.Methods: Commercial 13C-coils were used to estimate the transmit gain and center frequency for 13C and 23Na resonances. Simulations of the transmit B1 profile of a Helmholtz loop were performed. Noise correlation was measured for both nuclei. A retrospective analysis of human data assessing the use of the 1H resonance to predict [1-13C]pyruvate center frequency was also performed. In vivo experiments were undertaken in the lower limbs of 6 pigs following injection of hyperpolarized 13C-pyruvate.Results: The difference in center frequencies and transmit gain between tissue 23Na and [1-13C]pyruvate was reproducible, with a mean scale factor of 1.05179 ± 0.00001 and 10.4 ± 0.2 dB, respectively. Utilizing the 1H water peak, it was possible to retrospectively predict the 13C-pyruvate center frequency with a standard deviation of only 11 Hz sufficient for spectral–spatial excitation-based studiesConclusion: We demonstrate the feasibility of using the 23Na and 1H resonances to calibrate the 13C transmit B1 using commercially available 13C-coils. The method provides a simple approach for in vivo calibration and could improve clinical workflow.

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